Mock Exam: KPSC MOCK TEST KPSC QP 107 2023 OL

1

The molecular biology technique where RNA is converted to cDNA and then amplified is

2

Nucleic acid probes can be used for

3

In SDS-PAGE

4

The concept of real time PCR came because

5

In HPLC the resulting bands in the chromatogram are measured by

6

In a chromatographic instrument selective separation of a mixture occurs in

7

Drug of abuse can be measured by

8

Mass spectrometer identifies analytes based on

9

In atomic absorption spectroscopy with what material is the cathode in hallow cathode lamp made?

10

Prussian Blue stain is used for staining which of the following metals?

11

The Phenomenon by which an organic compound becomes excited when oxidised and emit light when it returns to ground state is

12

Regarding fluorometry which among these is true

13

The most sensitive detector in spectrophotometry is

14

Which of the following is true about Haemotoxylin and Eosin staining?

15

What is the ideal section thickness for preparing routine H and E stained sections?

16

Which among the following is true about reverse phase liquid chromatography/

17

What do you mean by bright field microscope?

18

The magnifying power of an eye piece in microscope is

19

Which among the following types of microscope does not require staining to view the slide?

20

Which among the following represents the correct stages of tissue processing?

21

All are true regarding active site of an enzyme except

22

Select the statement that is correct.

23

Turn over number

24

All are enzymes used as therapeutic agents except

25

All statements regarding isoenzymes are correct except

26

All are regarding the Michaelis constant (

K_m

) except

27

Which of the following statement(s) is/are correct about allosteric regulation? (i) Allosteric effectors can change either the

K_m

or the

V_{max}

of the reaction (ii) Homotropic interactions are always positive (iii) Most allosteric enzymes bind the allosteric effector with no effect on binding other ligands

28

All are used as immobilized enzymes except

29

Which of the following statements is/are correct? (i) The protein part of the enzyme is the prosthetic group (ii) The prosthetic group of the enzyme is called the co enzyme (iii) Co enzyme is a low molecular weight organic substance

30

An example of a lyase is

31

All are true regarding enzyme inhibition except

32

Which of the following statement(s) about immunochemical methods of isoenzyme analysis is/are correct? (i) Are particularly applicable to isoenzymes derived from multiple gene loci (ii) The greater discriminating power of monoclonal antibodies has potentially brought all multiple forms of an enzyme within the scope of immuno chemical analysis (iii) The most common routine methods to measure isoenzymes or isoforms are now based on immunochemical assays

33

Lineweaver-Burk plot is derived from

34

Example of enzyme induction is

35

An enzyme which undergo covalent modification by acetylation is

36

The pattern of appearance of an enzyme in blood after an acute injury depends on

37

Testing of AST in addition to ALT should be limited because

38

Which of the following statement(s) is/are true regarding pancreatic enzymes in acute pancreatitis? (i) Lipase measurement is superior to pancreatic amylase in terms of Diagnostic performance (ii) It is recommeded that lipase replace pancreatic amylase as initial test for acute pancreatitis (iii) The measurement of total amylase is recommended

39

True statement regarding unit of enzyme activity

40

All are examples of riboenzymes except

41

Which of the following is FALSE regarding EDTA contamination of blood sample?

42

All the following statements are TRUE regarding control materials EXCEPT

43

A gaussian curve is usually

44

Choose the INCORRECT statement regarding quality assessment in a health care laboratory

45

Systematic errors in lab. analytic processes can occur due to all the following EXCEPT

46

Quality control measures are used to minimize

47

All the following are measures of central tendencies EXCEPT

48

Westgard rule where control values are lying on one side of the mean should likely correspond with all EXCEPT

49

Levy Jennings chart is used for

50

POCT devices are all except

51

Which of the following DO NOT come under OSHA law and standards?

52

GLP certificate for laboratories in India is granted by

53

All of the following are TRUE about External Quality Control (EQC) except

54

Quality assurance scheme is necessary for

55

Choose the correct statement

56

The first enzyme to appear in the blood after a heart attack is

57

"Cardiomegalia glycogenica" is a characteristic of which of the following Glycogen Storage Diseases (GSDs)

58

Regulation of the electrolyte content of the body fluids is done by

59

In humans, the renal threshold for glucose per 100 ml of blood is

60

The phenomena of "Insulin resistance" is characteristic of

61

Jaundice (Icterus) occurs due to

62

"Inulin Clearance Test" is used to estimate

63

In HbA1C test for determining the severity of Diabetes, the glucose binds predominantly to which to amino acid of hemoglobin?

64

Lactate Dehydrogenase 5 (LDH-5 or M4) elevation in blood is indicative of

65

Assertion A: A bone marrow aspirate of a strictly vegetarian female, confirms the suspicion that she has a megaloblastic anemia because it showed a greater than normal number of red and white blood cell precursors, most of which were larger than normal. Reason R: Megaloblastic anemia mostly occurs due to Vitamin B12 deficiency also called as Cobalamin In the light of the above statements, Choose the correct answer from the options given below:

66

Assertion A: In a 30 year-old man fasting for several days, his brain reduces its need for glucose by using an alternate source of energy.\nReason R: Beta hydroxy butyrate is used as an alternate source of energy due to ketoacidosis.\nIn the light of the above statements, choose the correct answer from the options given below:

67

Statement I : During acute Myocardial Infarction, the test of Cardiac troponins, Serum myoglobin and Creatine Phospho kinase-MB (CPK-MB) can give the conclusive diagnosis.\nStatement II : During acute Myocardial Infarction, the test of Blood pressure, Lactate dehydrogenase and Choline esterase can give the conclusive diagnosis.\nIn the light of the above statements, choose the most appropriate answer from the options given below :

68

Identify correct statements about Glycogen and its storage disorders\n1. Glycogen is the major storage carbohydrate of animals and a branched polymer of

\alpha

-D-Glucose\n2. it occurs mainly in liver (upto 6%) and muscle where it rarely exceeds 1% of its weight\n3. liver glycogen is the readily available source of glucose for glycolysis.\n4. liver contains 3 to 4 times as much glycogen as does muscle\n5. Glycogen Storage Diseases (GSDs) are inherited disorders with abnormal deposition and deficient mobilization of gycogen.\nChoose the correct answer from the options given below :

69

In Jaundice (Icterus) excessive bilirubin catabolism and clearance occurs in the following sequence\n1. bilirubin formed in peripheral tissues is transported to the liver by plasma albumin\n2. bilirubin is conjugated with glucoronic acid by Bilirubin-UGT activity\n3. Uptake of bilirubin by liver parenchymal cells through facilitated transport system\n4. Secretion of conjugated Bilirubin into Bile by an active transport mechanism\n5. Bilirubin is derived from hemoglobin destruction, ineffective erythropoiesis and from other heme proteins like cytochrome P450\nchoose the correct answer from the options given below :

70

Insulin is released into the blood stream in response to hyperglycemia\n1. ATP sensitive

K^+

channels are inhibited causing membrane depolarization\n2. There is influx of

Ca^{2+}

ions within the

\beta

cells\n3. There is exocytosis of insulin into the blood\n4. The

\beta

cells of the Islets of Langerhans are freely permeable to glucose via. GLUT-2 receptors\n5. Glucose increases the metabolic flux and increases ATP production in the

\beta

cells\nChoose the correct answer from the options given below :

71

Ketosis that occurs in diabetic patients involve

72

Assertion A : Citrate anticoagulants have an important advantage over the oxalate anticoagulants\nReason R : Oxalate is toxic to the body, whereas moderate quantities of citrate can be injected intravenously.

73

Identify correct statements about blood clotting and anticoagulants :\n1. The anticoagulant of choice for blood cell counts is EDTA\n2. The anticoagulant suitable for storing blood for transfusion is dextrose, phosphate and citrate\n3. Anticoagulants are also called as Vasodilators\n4. In an anticoagulated specimen, the liquid part separated out from the blood is called as serum\n5. Heparin inhibits the conversatino of prothrombin to thrombin.\nChoose the correct answer from the options given below :

74

The functions of the synovial fluid includes all of the following except

75

Reverse Cholesterol Transport primarily involves

76

Choose the hormones which are nonapeptides

77

Find out the incorrect match : (Hormone − Signalling Pathway)

78

Which is the hormone that require parenchymal cells of more than one organ for its synthesis?

79

All the following hormones with common alpha sub units but with different beta subunit, except

80

The substrate of aromatase enzyme complex

81

All the following hormones are synthesized from Tyrosine, except

82

Acute decrease in the level of plasma ionized calcium stimulates the synthesis and secretion of

83

Antiotensin-Converting Enzyme (ACE) inhibitors are used to treat renin dependent hypertension because

84

Tyrosyl residues in thyroglobulin are iodinated to form thyroid hormones but iodinated free tyrosine cannot be incorporated into thyroglobulin to form thyroid hormones : Why?

85

The hormone that is not produced from a larger peptide precursor

86

Choose the correct matching sequence related to hormone action :\n(Hormone Hormone action via)

87

Different hormones and their urinary metabolites, useful to diagnose related disorders are given below. Find out the mismatch

88

The following are hormones of adipose tissue, except

89

False statement related to incretins

90

The rise in effective plasma osmolality stimulate the production and release of

91

Find out the incorrect match

92

Proteins used in therapy like insulin are produced by

93

Organic cation transporter OCT1 (SLC22A1) facilitates the movement across membrane of

94

The route of administration that reduce bioavailability by first pass effect

95

Drug effects that occur not by means of macromolecular receptors

96

True about median effective dose

97

Idiosyncratic reactions indicate

98

Choose the mismatch related to allergic reactions

99

An example of genotoxic carcinogen

100

Erethism is due to

KPSC Mock Test: Scientific Assistant (Biochemistry) - Medical Education

KPSC Mock Test: Scientific Assistant (Biochemistry) - Medical Education