KPSC-MOCK-TEST Mock Exam
KPSC Mock Test: Assistant Professor in Neurology - Medical Education Department
KPSC Mock Test: Assistant Professor in Neurology - Medical Education Department
Official Kerala Public Service Commission ONLINE Exam Question Paper & Answer Key. • Name of Post: Assistant Professor in Neurology - Medical Education Department • Department / Institution: (Cat No.336/2023 ) • Question Paper Code: 24/2024/OL- • Answer Key: Final Answer Key Question Paper PDF: https://www.keralapsc.gov.in/sites/default/files/2024-03/assi%20pro%20.pdf Answer Key PDF: https://www.keralapsc.gov.in/sites/default/files/2024-04/Final%20Answer%20key-%20Asst%20Professor%20in%20Neurology.pdf
100 Questions
Progress: 0 / 100 Answered
1
In muscle spindle, the term annulospiral endings is given for
2
Which nucleus of amygdala has connections with hypothalamus?
3
Neural groove is formed on Day
4
34 year old male presents with progressive distal Right upper limb weakness in the distribution of median and ulnar nerves with no sensory symptoms. What is the likely diagnosis?
5
A 45 year old male presents with weakness in left arm abduction and sensory loss over the lateral surface of the left upper arm and shoulder. Damage to which of the following structures of the brachial plexus may cause this presentation?
6
A 62-year-old man is seen for subacute onset of generalized weakness and gait changes with diffuse decreased reflexes and CIDP is suspected. Which of the following clinical and laboratory findings is concerning for the diagnosis of POEMS syndrome as opposed to CIDP?
7
A 44-year old man presents for evaluation of weakness. He reports the onset of difficulty in swallowing and weakness in his arms 3 year prior, which was initially attributed to statin therapy but has continued to progress off the statin. He reports progression of weakness and is detected to be diabetic. He has tongue and peri oral fasciculations, bilateral deltoid and iliopsoas weakness with atrophy and fasciculations. Absent ankle jerk; trace reflexes and flexor plantar and intact sensation. Which of the following additional features would be expected on examination?
8
A 13-year old boy presents with muscle pain and stiffness which is much worse in cold weather. In fact, few hours after exposure to cold, he felt quite weak as well as stiff. He had percussion myotonia at the thenar eminence and eye closure myotoria. Mutation in which of the following channels is mots likely responsible for his presentation?
9
Insular Lobe seizures are characterized by all except
10
20-year-old male presents for evaluation of abnormal movements. He initially developed dystonia of his left leg at 10 year of age, associated with walking and running. No response to levodopa, and trihexyphenidyl. He was successfully treated with Botulinum injections. However, he progressed to have dystonia in his right arm. His 57 year old father has Write's cramp and his younger sister has recently developed suspected dystonia in her legs. Mutation in which of the following genes is the most likely cause of the dystonia?
11
Which of the following is not a structure involved in the formation of new memories within the circuit of paper?
12
Associative visual agnosia is caused by a lesion in the
13
All the following statements are correct regarding Foville syndrome except:
14
Which of the following correlates with decorlicate rigidity?
15
A 30-year-old lady is evaluated for recurrent episodes of severe, repetitive stabbing pain in the right forehead and temple that is associated with ipsilateral conjunctival injection, tearing and photophobia. The attacks last between 1 and 2 minutes and occur atleast 100 times daily. Which of the following preventive measure is most likely to be effective in this patient?
16
A 16 year old girl has 6 months history of early night-time episodes characterized by sudden arousal from sleep, lifting her head and dystonic posturing of the extremities sometimes followed by getting out of bed and ambulating around the room for 1 to 2 minutes. There is a history of similar symptoms in her brother, father and paternal grandmother. Mutation of which of the following genes is most likely to be present in this patient?
17
A 64-year-old man presents with a 1 year history of progressive memory loss and more recent onset of abnormal movements of his arms, legs and trunk. Then he has obstructive sleep apnoea. His wife, who accompanies him describes odd movements during sleep in which he appears to be performing his previous work activities, such as threading wires. On examination, he has a vertical gaze palsy. What is the most likely diagnosis?
18
A girl presenting with DMD phenotype is most likely to be
19
Which is a CSF synaptic biomarker for Alzheimer's disease?
20
In which stage of intracerebral haemorrhage, both T1 and T2 MRI sequences are hyperintense?
21
Which of the following is one among the earliest electrophysiological finding in Guillain Barre syndrome?
22
Ear of lynx sign is seen in
23
False regarding QSART
24
Changing the filter settings on the EEG allows for all of the following except:
25
The intracellualr pathophysiological mechanism of an epiletiporm discharge is
26
In Transient Global Aphasia (TGA), the following are correct except
27
The anatomic structures of central importance in memory functions are the following except?
28
The following is an example of implicit memory except?
29
The following are related to features of depression except?
30
The following are examples of subcortical dementias except?
31
Following Hemtopoietic Stem Cell Transplantation (HSCT) the following neurological complication can occur except?
32
The following drugs will produce cerebellar syndrome
33
Botulinum toxin A bind to following synaptic vesicular protein
34
Clinical improvement after the use of Edrophonium are seen in the following conditions except?
35
Therapeutic options for ADEM are except
36
Reye Syndrome is characterized by following except
37
Monoclonal antibodies are used in Multiple Sclerosis are the following except
38
Evoked Potentials used in early stages of Multiple Sclerosis or spinal form of multiple sclerosis are following except
39
Multiple Sclerosis in conjunction with peripheral neuropathy indicative of following except
40
Recurrent myelitis at one level of spinal cord without any other signs of demyelinating disease can be found in except?
41
JC Virus causing Progressive Multifocal Leukoencephalopathy by attacking which cells of brain?
42
In SSPE histopathological changes are not observed in following part of brain?
43
Infections that follow neurosurgery or the insertion of cranial appliances are usually due to
44
Eosinophilic meningitis is caused by following except
45
Drugs used for treating CNS toxoplasmosis are except
46
CNS Aspergillosis can occur as a complication of the following except?
47
Risk of stroke is implicated with polymorphism of which chromosome?
48
CHADS2 and CHA2DS2-VASC are scoring system to predict the risk of stroke following
49
Hollenhorst plaque is get in which organ?
50
Blood supply of Globus Pallidum is by
51
Transmantle sign is seen in the Magnetic Resonance imaging of which of the following conditions causing epilepsy?
52
Which among the following statements is/are true regarding responsive Neurostimulation (RNS) treatment in epilepsy?
I. It is synonymous with adaptive Deep Brain Stimulation
II. Epilepsy arising from loci in the eloquent cortex is the major contra-indication for RNS
III. It is a form of closed-loop neurostimulation
IV. Useful in those with poorly localised or multi-focal epilepsy in whom resective surgery is contra-indicated
53
Synaptic Vesicle Protein 2A (SV2A) mediates the anticonvulsant effects of which of the following anti-seizure medications?
I. Lacosamide
II. Levetiracetam
III. Rufinamide
IV. Stiripentol
54
Which among the following statements is true regarding Gastaut Syndrome?
55
Epileptogenic Zone is most accurately defined as
56
Mutations in which among the following genes is related to Autosomal Dominant Epilepsy with Auditory Features (ADEAF)?
57
Select the correct statement/statements regarding the physiology of sleep and wakefulness.
I. Cholinergic neurons located close to mesopontine junction are involved in maintenance of wakefulness.
II. The major neurotransmitter for sleep-wake cycle, hypocretin, comes from neurons in the tuberomammillary nucleus.
III. Neurons in the median preoptic nucleus are involved in the initiation of sleep.
IV. Neurons in the lateral hypothalamus form the major source of histamine in the physiology of sleep
58
Which among the following is classified as a parasomnia in the international classification of Sleep Disorders?
59
The "3P Model" or the Spielman model is the most widely accepted theoretical model of
60
The neurotoxin beta-N-oxalylamino-L-alanine (L-BOAA), responsible for lathyrism, is a:
61
Skewed Lyonization impacts the clinical manifestations of which among the following diseases?
62
Which among the following statements regarding Upper Motor Neuron (UMN) Disorders is correct?
I. Spastic Paraplegia 2 due to PLP1 mutations is inherited as an autosomal recessive condition.
II. Konzo is a myelopathy predominantly seen in T anzania and results from Human T Lymphotropic Virus T ype 2 infection.
III. Primary Lateral Sclerosis is a diagnosis of exclusion.
IV. Magnetic Resonance Spectroscopy shows reduction in choline relative to N-acetyl aspartate in patients with UMN syndrome in motor neuron disease.
63
T ofersen is a novel drug being tried in the treatment of Amyotrophic Lateral Sclerosis resulting from mutation in which among the following genes?
64
Which among the following medications modulates the splicing of the Survival Motor Neuron 2 (SMN2) pre-mRNA?
65
A 65-year-old lady comes to you with frequent headaches which are exclusively nocturnal. The headaches wake her up from sleep almost every night around midnight. The headache may last from 20-30 minutes, sometimes up to 2 hours. No medical comorbidities were reported. No abnormalities were found on clinical examination and baseline laboratory tests and MR imaging of brain were reported normal. Which among the following medications is likely to help this patient?
66
Which among the following neurons in the cerebellum are glutaminergic and excitatory?
67
All the following Spinocerebellar Ataxias (SCAs) are caused by polyglutamine-coding CAG repeat expansions, EXCEPT
68
Select the correct statement/statements regarding autosomal recessive ataxias.
I. In Ataxia T elangiectasia Like Disorder, serum Alphafeto Protein (AFP) levels are typically normal.
II. Serum AFP levels are elevated in Ataxia with Oculomotor Apraxia T ype 2.
III. Lymphoid cancer risk in Ataxia with Oculomotor Apraxia T ype 2 is even higher than Ataxia T elangiectasia.
IV. Ataxia with Oculomotor Apraxia T ype 1 is associated with immunodeficiency.
69
The delayed-start study design is used to:
70
Which among the following "apraxias" is most likely to occur as a treatment-related complication in patients with Parkinson's diease undergoing bilateral subthalamic nucleus deep brain stimulation?
71
Which among the following is a 3 Repeat (3-R) tauopathy?
72
The landmark clinical trial, PD-MED, whose results were published in 2014, compared which of the following therapies in Parkinson's disease?
73
What is the approximate penetrance in DYT-TOR1A (TOR-1A Associated dystonia)
74
Which among the following is the most characteristic histological features linking the different types of Multiple System Atrophy?
75
Ambroxol, which has been tried as a candidate drug for repurposing for the treatment of Parkinson's disease, acts on which of the following mechanisms?
76
Identify the correct statement
77
Identify the incorrect combination.
78
Predominant upper limb motor involvement is the typical pattern in all except
79
Treatment for self-multilation in Autistic Spectrum Disorders include all of the following except
80
A 32-year, premorbidly normal lady, developed gait unsteadiness followed by double vision and drooping of eyelids. She had mild sore throat a week ago and clinical examination revealed bilateral external ophthalmoplegia, subtle bifacial weakness and ataxia. The most likely diagnosis.
81
In Hereditary Neuropathy with Liability to Pressure Palsies (HNPP), the most frequently affected never is
82
Features of Musk-Antiboidy Myasthenia Gravis include all except
83
"Ice pack test" in Myasthenia Gravis
84
Thymectomy for Myasthenia Gravis (MG)
85
Which of the following statement is wrong about Lambert-Eaton Myasthenia (LEM)?
86
Incorrect statement about Congenital Myasthenic Syndrome
87
In the treatment of Duchenne Muscular Dystrophy (DMD) which of the following is incorrect?
88
Sudden death secondary to fatal arrhythmias is common in
89
Asymmetric weakness, deltoid sparing and Positive Beevor sign seen in
90
Incorrect about Immune mediated Myopathy associated with Anti-HMGCoA Reductase antibodies
91
Muscle infiltration with aberrant large granular T lymphocytes may be seen in which of the following?
92
Which of the following is not known to produce 'secondary pseudotumor cerebri'?
93
Low cerebellar tonsils, crowding of the posterior fossa, small prepontine cistern and inferior displacement of the optic chiasm are seen in
94
Which of the following is not an anti-migraine agent?
95
Identify the incorrect statement about SUNCT and SUNA.
96
Pain felt deep in the auditory canal is suggestive of
97
Which of the following is not an atypical features in Dyslexia?
98
Which of the following could be permitted for use in patients with Porphyria?
99
A 16-year-old was operated for vestibular schwannoma on both sides within a span of 2 years. What is ophthalmological finding most commonly encountered?
100
Which of the following is atypical for Panayiotopoulos Syndrome?
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