Mock Exam: KPSC MOCK TEST KPSC QP 27 2023 OL

1

Which of the following pair is correct about solubilizers and the bond they disrupt?

2

Which among the following substituents enhance fluorescence of a compound? (i) -OH (ii)

-NO_2

(iv) -COOH

3

Nuclei that do not have possess spin property includes (i)

^{12}C

(ii)

^{13}C

(iii)

^{16}O

(iv)

^{31}P

4

Give the right sequence of RT-PCR (i) Taq polymerase extends target sequences (ii) Extract poly(A)+RNA (iii) Oligo primers bind to target sequences (iv) Extend with reverse transcriptase to form cDNA (v) ds cDNA denaturated by heating to >94°C (vi) Anneal Poly(dT) primer

5

Which of the following is true for achromat objective lenses in a microscope? (i) They are cheapest objective lens (ii) They are corrected for spherical aberrations with green light (iii) They are best used when the light source utilizes a green filter and images are collected in grayscale (iv) They are spherically corrected for three wavelengths

6

Select the correct pair of luminescence system and measured moiety.

7

Choose the right facts in Connection to PAGE

8

Match the following:

9

Select the group consisting of compounds belonging to alkaloid class

10

Which of the following is true about function of alkaloids? i. Reserpine which lowers blood pressure ii. Cocaine is an anaesthetic iii. Vincristine is cytotoxic agents iv. Anthocyanins play an important role in insect mimicry

11

Which of the following does not belong to the class of phenolic compound?

12

From which among the following is etoposide derived from?

13

Choose the set of secondary metabolites.

14

____________ is the secondary metabolite obtained from 'tree of joy'.

15

The techniques that help to determine functional group present in isolated secondary metabolite of a plant is

16

Choose the correct test to detect the presence of glycosides in plant extract.

17

On shaking plant extract with acidified chloroform and allowing to stand, yellow colour appears in lower layer. Presence of which phytochemical is indicated by this test?

18

An enzyme with nomenclature EC 2.7.3.2 belongs to ___________ class.

19

The sets of enzymes that are markers of myocardial infarction

20

Which of the following statement is correct?

21

Bell shaped curve is obtained for enzyme velocity with

22

Select the false statement regarding active site of enzyme.

23

Km value is unchanged while Vmax is lowered in

24

Which of the following is different from rest of the inhibitors?

25

Choose the correct pair of coenzyme and corresponding vitamin.

26

For plot of V against [S], allosteric enzyme exhibits

27

Acute pancreatitis is characterised by

28

Choose the incorrect statement.

29

Bragg equation states that

30

Pick out the right statement regarding MALDI-TOF MS.

31

Mammalian cells use several cdks and cyclins to regulate passage through the cell cycle. Match the correct combinations which regulate the different phases of the cell cycle. Cdks, Cyclins, Cell cycle phases 1. Cdk1, a. Cyclin A, i.

G_1

phase 2. Cdk2, b. Cyclin B, ii.

S

phase 3. Cdk4, c. Cyclin D, iii.

G_2

phase iv.

M

phase

32

The following are the molecular cancer biomarkers used to diagnose cancer in the human body. Find the correct combination of markers used to identify the different types of cancer A. AFP B. HER-2 C. CA-125 D. CEA i. Breast cancer ii. Colorectal cancer iii. Liver cancer iv. Ovarian cancer

33

Movement of

Na^+

through open voltage-gated

Na^+

channels is driven by

34

Select the incorrect statements concerning membrane proteins A. The plasma membrane of the cell contains 50% of the proteins by mass B. The transmembrane proteins are amphipathic and can function on both sides of the bilayer or transport molecules across it C. Mutation (V509A) in integral membrane protein thyrotropin receptor leads to congenital hypothyroidism D. Peripheral membrane proteins are permanently attached to one face of a membrane by noncovalent interactions with other membrane proteins and involve in cell signalling

35

The statements below address receptor-mediated endocytosis. Which of the following statements about receptor-mediated endocytosis is true? A. In receptor-mediated endocytosis, the extracellular materials bind to complementary receptors on the cell surface and enter the cell B. GGA adaptor molecule associated with clathrin-mediated endocytosis C. Receptor-mediated endocytosis (RME) leads to the formation of mannose-coated pits D. Dynamin is a large GTP-binding accessory protein that aids in the release of the clathrin-coated vesicle from the membrane

36

Which of the following describes the effective dose of the drug?

37

Match the following drugs with their General targets Drugs, General Targets A. Rifampicin, i. Act on 30S subunit of ribosome and block the protein synthesis B. Tetracycline, ii. Binds to RNA polymerase and interferes transcription process C. Cephalosporins, iii. Act on 50S subunit of ribosome and block the protein synthesis D. Erythromycin, iv. Inhibit the cell wall synthesis

38

Which of the following statement about Cytochrome P450 is false?

39

Which of the following reaction doesn't involve phase II of drug metabolism

40

Match the bacterial toxins with their mode of action Toxins, Mode of action A. Pertussis toxin, i. Inhibit neurotransmitter release in a neuron B. Diphtheria toxin, ii. Selective blockers of acetylcholine release from nerve endings C. Botulinum toxin, iii. Inactivates elongation factor (EF-2) and inhibits protein synthesis D. Tetanus Toxin, iv. Inactivities G proteins and blocks the signal transduction

41

Carbonyl group show

n \rightarrow \pi^*

somewhere in ultraviolet region, but their 2,4 dinitrophenylhydrazone derivatives show

\pi \rightarrow \pi^*

in the visible region. This is due to

42

Hypersensitivity reactions can be classified into four types. Which of the following types has correctly matched concerning its immune responses? A. Type I - IgE mediated immediate reaction B. Type II - Immune complex-mediated reaction C. Type III - Antibody-mediated cytotoxic reaction (IgG or IgM antibodies) D. Type IV - Cell-mediated, delayed hypersensitivity reaction

43

Which of the following statement is false with respect to type III Hypersensitivity reaction

44

Which of the following statements are not true about drug addiction? A. Drugs of abuse cause the brain's limbic system to release dopamine, the neurotransmitter that produces feelings of pleasure B. Drug tolerance makes people need more and more of the same drug because, over time, drugs will cause the brain to produce less dopamine C. Marijuana and heroin can activate neurons because their chemical structure mimics that of a natural neurotransmitter in the body D. Cocaine and amphetamines directly increase extracellular dopamine by blocking the presynaptic dopamine transporter (DAT)

45

46

Drug distribution will be influenced by A. Tissue/organ blood flow B. Physicochemical properties of the drug C. Influx and efflux transporters D. Plasma protein and tissue binding

47

The complement system is a potent mediator of inflammation and destruction and could cause extensive damage to host cells if uncontrolled. The complement system is tightly regulated by inhibitory/regulatory proteins. The following is the list of the key regulatory proteins that regulate the complement system. Match the regulatory proteins of the complement system with the stated functions. | Regulatory Proteins | Functions | | :--- | :--- | | A. CI Inhibitor | i. Enzymatically inactivities C4b and C3b | | B. DAF | ii. Promotes C3b and C4b inactivation | | C. MCP | iii. Binds to C1r and Cls prevents further activation of C4 and C2 | | D. Factor I | iv. Inactivates C3b and C4b |

48

Which of the following statements regarding the live attenuated vaccine is incorrect?

49

Which of the following method is currently used to deduce the evolutionary relationship between bacteria?

50

Multidrug resistance in bacteria may be generated by A. Horizontal gene transfer B. Mutations in the DNA C. Enzymatic Inactivation of the Drug D. Increased expression of genes that code for multidrug efflux pumps

51

52

If the centre of gravity of a molecule changes during motion, then the molecule have,

53

Identify the correct statement from the following A. Spectroscopy is the study of the interaction between matter and radiated energy B. Spectrometry is a practical measurement in the atomic and molecular balances of matter C. Spectroscopy is a theoretical method of science that does not produce any results D. Spectrometry the study of matter's absorption properties or absorption behaviour when exposed to electromagnetic radiation.

54

When we consider Raman scattering spectrum, and if we designate the intensities of the most intense lines of the stoke lines, Anti stokes lines and Raleigh scattering are

I_s

,

I_{as}

and

I_r

respectively, the the inceasing order will be

55

Select the false statement(s) from the following A. As bond order decreases, bond energy as well as force constant increase B. As bond energy increases, bond length decreases and force constant increases C. As bond length increases bond energy decreases and force constant also decreases D. As force constant decreases, bond length decreases and bond energy increases

56

The expected number of ESR signals for methyl free radical and benzen anion are respectively

57

Which one of the following is false for Doppler broadening of spectral lines

58

Identify the statement regarding the reference molecule used in NMR spectrsocopy A. TMS will give weak NMR absorption even in dilute solutions B. The Shielding of protons in TMS is greater than in most organic molecules C. The methyl group of DSS resonate at a different position of the methyl group of TMS D. DSS or its sodium salt is more often used as calibration standard of NMR for protein experiments in water

59

The transitions of the electron between the molecular orbitals for the absorption in the region 200 to 800 nm is not possible for

60

Which of the following are the Quantum mechanics methods used in computational chemistry

61

Which of the following statement(s) are correct A. Glass electrode only compares pH values while the hydrogen electrode measure pH absolutely B. The pH values measured by quinhydrone electrode are very accurate even in the presence of oxidising ions C. Potentiometry is a method of electroanalysis is used to find the concentration of a solute in a solution D. Amperometry is the technique to detect the ions in a solution depending on electric voltage or changes in redox potential

62

The Electrokinetic phenomenon in which the movement of particles causes potential is

63

Which of the following is not suitable for Amperometry?

64

The salts of a given metal can be arranged in order of their decreasing ability to remove lyophilic substances from colloidal solution. This series is called

65

Identify the correct statements A. During gelation there is a large increase in viscosity B. Imbibation pressure breaks the soil around the seeds during germination C. A small amount of electrolyte increases the zeta potential of lyophilic colloids D. Critical Micellar concentration decreases as the molecular weight of a hydrocarbon chain increases

66

Identify the correct statements(s) from the following\nA. Regioselectivity of the hydroboration step can be improved with bulky boranes\nB. For mono-substituted cyclohexane, the equatorial conformer is more stable than the axial-conformer because of the 1,3- diaxal interaction\nC. Hydroboration/Oxidation proceeds in an Anti-Markovnikov manner, where the hydrogen from

BH_3

or

B_2H_6

attaches to the more substituted carbon\nD. Addition of

H_2O

to a carbon carbon double bond is Markovinikov syn addition

67

If we consider trans-1-t-butyl-3 methylcyclohexane, in its most stable conformation, then the substituents at C1 and C3 are

68

Which one of the following could be grouped as prochiral molecules?

69

Cyclopentadiene is more acidic than cyclopentane, because

70

The mechanism of oxymercuration of an alkene to yield an alcohol follows

71

The alkaloid pilocarpine extracted from the leaves of pilocarpus microphyllus is an

72

In IR spectraum of para nitro phenyl acetate, Carbonyl absorption band may range on

73

How many peaks could be expected in the proton decoupled

^{13}C

NMR spectra of 1-methyl cyclohexene and methylcyclohexane respectively?

74

Which one of the following group of compound belongs to T erpenes?

75

What is the correct order of

\lambda_{max}

for n->

\pi^*

transition for the following organic groups, R-N=N-R, R-CN and R-CHO?

76

Which among the following statements are correct?\nA. Ninhydrin is sprayed to locate amino acids and on applying ninhydrin amino acids will be appeared in pink to purple colour\nB. The four main system in HPLC are mobile phase reservoirs Injector system, column and detector\nC. Gas chromatography is a type of adsorption chromatography in which the mobile phase is a gas\nD. Elutropic series is a series of various compounds in order of adsorbtion power for a given adsorbent

77

Which of the following set of reactions are given by citral?

78

During ion exchange separation, ion exchange is favoured at higher concentration, when

79

Identify the wrong statement(s) from the following\nA. In GC-MS the compounds to be analysed must be suﬃcienly volatile and thermally stable\nB. The gas chromatograph utilises a capillary colomn which does not depend upon colomn's dimension as well as the phase properties\nC. Electrospray ionisation method in LC-MS can be used for highly polar, highly stable or thermally stable compounds\nD. Carrier gas used in GC-MS are nitrogen helium argon and Hydrogen

80

Crypton is a natural terpenoid which

81

Which among the following is the function of Chopper in AAS?

82

A

M

solution of potassium permanganate has a transmittance of 20% when measured in a 2.10 cm cell at a wavelength of 525nm. The molar absorptivity of potassium permangnate solution is

83

If DTA of

CaC_2O_4 \cdot H_2O

is carried out in an inert atmosphere, the number of exothermic peaks are

84

Statement I : SEM is least appropriate for small particles\nStatement II: Small nanoparticles contribute very little to the signal obtained by SEM. Find the correct option from the following

85

Which of the following is a greener route to produce ethanol commercially?

86

The term Cryptand refers to

87

Which of the following is an anion receptor?

88

Which enzyme regulates the external signal ﬂapping in the molecular switches?

89

Supramolecular Calixarenes contain

90

Molecular T weezers is primarily concerned with

91

Predict the correct order of magnetic moment for the following geometry pf Ni(II) complexes

92

Which of the following statement is incorrect about Zeise's salt?

93

Indicate the number of Mossbauer peaks in the spectrum of

Fe(CO)_5

94

How many metal-metal bonds are present in

Fe_3(CO)_{12}

?

95

Ferrocene cannot undergo which of the following reactions?

96

The order of CO infrared stretching frequencies in

Ni(CO)_4, [Co(CO)_4]^-, [Fe(CO)_4]^{2-}

is

97

The oxidation state of iron in methemoglobin is

98

If ATPase pumps 6

H^+

out of the cell and 4

H^+

into the cell, the number of ATP consumed

99

Identify the correct statement for the EPR spectrum of

VO(acac)_2

[with square pyramidal geometry at Vanadium ] at 77K [I value of

^{51}V = 7/2

]\nA. It has two g values\nB. It has one g value\nC. It has 8 lines only\nD. It has 2 patterns of 8 lines

100

For the given complex

[Mo(CN)_8]^{4-}

, the coordination number and geometry respectively, are

KPSC Mock Test: Research Officer- Chemistry/ Biochemistry - Ayurveda Medical Education Drugs Standardisation Unit

KPSC Mock Test: Research Officer- Chemistry/ Biochemistry - Ayurveda Medical Education Drugs Standardisation Unit