Mock Exam: KPSC MOCK TEST KPSC QP 30 2024 OL

1

MaGIC risk stratiﬁcation is related to :

2

All the following are risk reduction strategies in BRCA mutated individuals except

3

Which of the following will have very low/no risk of prolonged Azoospermia?

4

Which of the following is the preferred method to establish tissue diagnosis of cutaneous melanoma?

5

Cancer immune editing includes all except

6

Which of the following is not a factor used in the prognostication of advanced stage Hodgkin lymphoma by the International Prognostic Score (IPS)?

7

What is the treatment of choice for solitary plasmacytoma?

8

MRD negativity in ALL and MMR in CML:

9

A 45 year old gentleman underwent endoscopic removal of a colonic polyp. Which of the following is NOT an indication for colon resection surgery?

10

A 50 year-old patient presents with breast cancer involving axillary and infraclavicular lymph nodes and exhibits a pCR at mastectomy and sentinel node biopsy following neo adjuvant chemotherapy. What is the current standard of care for adjuvant RT?

11

What is the most common type of small bowel malignancy?

12

Which is the most common tumour suppressor gene mutation in pancreatic cancer?

13

Platelet dysfunction is seen with

14

Which of the following is not included in 5 A's model of smoking Cessation?

15

Among the following, routine antiemetic prophylaxis can be avoided in all except:

16

Which drug-adverse event is wrongly matched?

17

All of the following are indication for annual screening MRI of breast except

18

All of the following are indication for surgical biopsy after core needle biopsy except

19

Anthracyclines inhibit:

20

All of the following tumours are positive for CD 30 except:

21

ENDURANCE trial studied newly disgnosed patients with Multiple Myeloma. All are true except

22

B/I prophylactic mastectomy - decreases the breast cancer risk by

23

Which of the following is not a component of Gail model for breast cancer risk estimation?

24

The statement regarding dermatofibrosarcoma protuberans is true except:

25

Which feature is NOT a criterion for MGUS?

26

In CML, presence of which of the following points towards poor prognosis?

27

Oberlin criteria is used in which malignancy?

28

All are acquired resistance genes in NSCLC except

29

For which of the following cancers is alcohol consumption not a risk factor?

30

Which is most accurate regarding risk factors for breast cancer?

31

According to the Society of Surgical Oncology, American Society for Radiation Oncology and American Society of Clinical Oncology Consensus Guidelines, which statement regarding Breast-Conserving Surgery (BCS) in ductal carcinoma in situ is most accurate?

32

Regarding the use of High dose methotrexate, choose the CORRECT statement.

33

Regarding induction therapy of Acute myeloid leukemia in older adults, which is TRUE?

34

Which of the following is a suitable agent for tackling positive MRD status in acute lymphoblastic leukemia?

35

Which of the following is NOT an inhibitor of VEGF?

36

Regarding CDK4/6 inhibitors in hormone-positive breast cancer, choose the CORRECT statement.

37

Which of the following is NOT TRUE regarding DNA repair and use of PARP inhibitors?

38

Which of the following is the target of lenalidomide?

39

Regarding the mechanism of action of anti-emetic agents, choose the CORRECT statement.

40

Regarding the management of toxicities of BTK inhibitors, choose the CORRECT statement.

41

Regarding immune therapy (Check point inhibitors) related AE (irAE), which is the TRUE statement?

42

A 46-year-old male with NSCLC, Adenocarcinoma, PDL1 60%, is started on Pembrolizumab. After 6 weeks, when he presents for his 3rd dose, he complains of abdominal pain and increased stool frequency upto 5 times a day, with occasional streaks of blood. His CBC, RFT, LFT, TSH and Cortisol levels are normal. Which of the following is a TRUE statement regarding further management of the current problem?

43

Regarding cytokine release syndrome associated with immune therapies, choose the CORRECT statement.

44

Regarding ALK mutated lung cancer and ALK inhibitors in lung cancer, choose the INCORRECT statement.

45

A 50-year female with ER+ve, PR-ve, Her-2 2+ (FISH negative) breast cancer with metastatic disease is treated with first-line paclitaxel and has progressive disease while on letrozole and palbociclib. Which of the following would NOT be a reasonable choice of treatment for her?

46

Regarding de-escalation of therapy in ER-positive, early breast cancer using gene profiling (Oncotype Dx), choose the TRUE statement.

47

A 45-year-old male presents with 3 week history of cough and hemoptysis. He has a large lung lesion and multiple liver metastases. Bilirubin is 2.5 mg/dL. He has dyspnea. He has several bone lesions with pain. Biopsy is adenocarcinoma. The NGS panel is negative. PDL 1 is 50%. Which of the following is the most appropriate therapy?

48

Regarding the infusion of paclitaxel, choose the CORRECT statement.

49

Which of the following is an absolute contraindication for rechallenge with any form of L-asparaginase in a patient with Acute lymphoblastic leukemia?

50

Regarding Daratumumab used in myeloma, please choose the CORRECT statement.

51

A 54-year-old male presents with hematuria. The evaluation shows a bladder tumor (biopsy : urothelial carcinoma) and PET CT shows bilateral lung metastasis and retroperitoneal and pelvic lymphadenopathy. He is ECOG PS 1 and has normal renal and liver functions. The first line treatment of choice for him would be :

52

Which of the following is not correct about Superior Venacava Syndrome (SVCS)?

53

Which of the following statement(s) is/are correct? I. CAR T-cell therapy - diffuse cerebral edema II. L-asparaginase - dural venous sinus thrombosis III. ATRA - idiopathic intracranial hypertension

54

MNOP algorithm is used for the management of the following oncologic emergency

55

Which of the following Laboratory abnormality is not seen in tumor Lysis syndrome?

56

Which among the following is the most common etiology of hypercalcemia seen in cancer patients?

57

The most common type of classical Hodgkin Lymphoma is

58

According to EORTC criteria to stratify early stage Hodgkin Lymphoma, which among the following is not a risk factor?

59

Which among the following statement(s) is/are correct? I. t(11;14) is a characteristic chromosomal translocation found in Burkitt's lymphoma II. Plasma cell neoplasms usually express CD 138 III. Phenytoin use is associated with increased risk of developing NHL

60

Which among the following is not a FDA approved PIK-3 inhibitor for patients with relapsed and refractory follicular lymphoma?

61

Which among the following statement is not true about HIV associated NHL?

62

According to revised European Leukemia/Net classiﬁcation system of AML, which among the following is an adverse risk category?

63

Which among the following are FDA approved treatment options for primary refractory/relapsed adult ALL?\nI. Blinatumomab\nII. Inotuzumab ozogomycin\nIII. Tisagenlecleucal

64

Which among the following is not a Myeloma Deﬁning Event (MDE) according to international myeloma working group revised diagnostic criteria?

65

Which among the following TKI is/are active in CML patients with T315I mutation?\nI. Ponatinib\nII. Bosutinib\nIII. Nilotinib\nIV. Asciminib

66

SEQUOIA trial is associated with which of the following agent?

67

_______________ is deﬁned as having smoked fever than 100 cigarettes in a person's lifetime and no current cigarette use.

68

The increased risk of malignancy associated with obesity is strongest in

69

Which among the following statements about nutrition and cancer risk are true?\nI. Diet rich in calcium decreases colon cancer.\nII. Diet high in glycemic load increases risk of endometrial cancer.\nIII. Coﬀee consumption associated with decreased risk of liver cancer.

70

According to 2017 AJCC staging of regional node involvement (non HPV associated oropharyngeal cancer) metastasis to a single ipsilateral node with extranodal extension is

71

Among the following, the most common mutation observed in adenocarcinoma lung is

72

Deﬁciency of the following micro nutrient in diet is associated with increased risk of esophageal squamous cell carcinoma

73

Aﬂatoxin is associated with increased risk of

74

Which among the following is not a preferred agent for breast cancer risk reduction in high risk post menopausal women?

75

Which of the following is not a side eﬀect of T amoxifen?

76

Which of the following is not associated with Small Cell Lung Carcinoma (SCLC)?

77

A 52 year old male, is diagnosed as a case of nasopharyngeal squamous cell carcinoma, moderately diﬀerentiated, with bilateral cervical lymph nodes and multiple lung metastasis. Which agent along with chemotherapy in the ﬁrst line has shown progression free survival and overall survival beneﬁt in this setting as per the JUPITER 02 trial?

78

As per the TNM Staging System for Cervical Lymph Nodes and Unknown Primary T umors of the Head and Neck (8th edition AJCC), a 48 year old lady is designated N2 U status. What does U stand for?

79

What is the ﬁrst line recommended systemic treatment for metastatic triple negative breast cancer with PDL1 CPS<10 and no germline BRCA1/2 mutation?

80

Name the genomic prognostic tool that was explored in the APT trial update.

81

Which is the bispeciﬁc T-cell engager (BiTE) agent which has demonstrated promising survival outcomes in advanced small cell lung cancer?

82

56 Year old with metastatic adenocarcinoma of lung is on Trametinib. For which side eﬀect, would you permanently discontinue the drug?

83

Which is the ﬁrst oral selective ER degrader which is approved for ER positive, HER2 negative advanced breast cancer patients with ESR1 mutations following at least one prior line of endocrine therapy?

84

Most common subtype of basal cell carcinoma is:

85

T ebentufusp-tebn is approved for the treatment of

86

Adagrasib is approved for the systemic treatment of

87

Along with chemotherapy, which of these agents are approved for the primary treatment of endometrial cancer?

88

What is the dose of IV Methotrexate in standard EMACO regimen?

89

What is the gold standard for identifying POLE mutation?

90

What are the treatment groups compared in TIGER trial for relapsed testicular germ cell tumors?

91

Pemigatinib, a selective ﬁbroblast growth factor receptor inhibitor is approved for the treatment of which of these malignancies?

92

A 60 year old male is diagnosed with metastatic gastrointestinal stromal tumor with a platelet-derived growth factors receptor alpha (PDGFRA) exon 18 mutation - PDGFRA D842V. Which is your preferred systemic agent?

93

Which among the following is a high risk factor when adjuvant treatment for stage II carcinoma colon is considered?

94

What is N2b in the TNM staging for rectal cancer as per AJCC 8th edition?

95

Compadri regimen is used in the treatment of

96

PAX3-FOXO1 molecular abnormality is mostly associated with

97

Steinherz/Blayer algorithm is related to:

98

'High risk sites' in Langerhans cell histiocytosis is all, except:

99

As per Modiﬁed Change staging system for posterior fossa medulloblastoma metastasis, what is the notation for gross nodular seeding in spinal subarachnoid space?

100

What is the treatment of stage I Wilms' tumor, with focal anaplasia and no loss of heterozygosity 1p and 16q?

KPSC Mock Test: Assistant Professor in Medical Oncology - Medical Education Department

KPSC Mock Test: Assistant Professor in Medical Oncology - Medical Education Department